diff --git a/Lib/test/test_typing.py b/Lib/test/test_typing.py
index f9a067bc0dfd466e8f0c26bb3c529329e0ca49bd_TGliL3Rlc3QvdGVzdF90eXBpbmcucHk=..3887d297d1e41cd2f6f63dd2d16cdb34a0ea82af_TGliL3Rlc3QvdGVzdF90eXBpbmcucHk= 100644
--- a/Lib/test/test_typing.py
+++ b/Lib/test/test_typing.py
@@ -2267,6 +2267,12 @@
         with self.assertRaises(TypeError):
             issubclass(int, ClassVar)
 
+    def test_bad_module(self):
+        # bpo-41515
+        class BadModule:
+            pass
+        BadModule.__module__ = 'bad' # Something not in sys.modules
+        assert(get_type_hints(BadModule), {})
 
 class FinalTests(BaseTestCase):
 
diff --git a/Lib/typing.py b/Lib/typing.py
index f9a067bc0dfd466e8f0c26bb3c529329e0ca49bd_TGliL3R5cGluZy5weQ==..3887d297d1e41cd2f6f63dd2d16cdb34a0ea82af_TGliL3R5cGluZy5weQ== 100644
--- a/Lib/typing.py
+++ b/Lib/typing.py
@@ -1628,7 +1628,10 @@
         hints = {}
         for base in reversed(obj.__mro__):
             if globalns is None:
-                base_globals = sys.modules[base.__module__].__dict__
+                try:
+                    base_globals = sys.modules[base.__module__].__dict__
+                except KeyError:
+                    continue
             else:
                 base_globals = globalns
             ann = base.__dict__.get('__annotations__', {})
diff --git a/Misc/NEWS.d/next/Library/2021-04-12-06-01-10.bpo-41515.YaVReb.rst b/Misc/NEWS.d/next/Library/2021-04-12-06-01-10.bpo-41515.YaVReb.rst
new file mode 100644
index 0000000000000000000000000000000000000000..3887d297d1e41cd2f6f63dd2d16cdb34a0ea82af_TWlzYy9ORVdTLmQvbmV4dC9MaWJyYXJ5LzIwMjEtMDQtMTItMDYtMDEtMTAuYnBvLTQxNTE1LllhVlJlYi5yc3Q=
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2021-04-12-06-01-10.bpo-41515.YaVReb.rst
@@ -0,0 +1,2 @@
+Fix :exc:`KeyError` raised in :func:`typing.get_type_hints` due to
+synthetic modules that don't appear in ``sys.modules``.